Chunhui Liu，Ph.D.
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Associate Professor
School of Pharmaceutical Sciences, Shandong University
44 West Wenhua Rd, Jinan 250012
Tel: 86-531-88380288
Email: liuchunhui@sdu.edu.cn |
Education
2003-2006 Ph.D in Biopharmaceutical Science, China Pharmaceutical University, Nanjing
1995-1998 M.S. in Ecology and Biodiversity, Shandong University, Jinan
1991-1995 B.S. in Modern Biology, Department of Biology, Shandong University
PROFESSIONAL EXPERIENCE
2012 – 2013 Visiting Scholar & Visiting Scientist-CBMC, School of Pharmacy, University of North Carolina at Chapel Hill
2010 – Present Associate Professor, School of Pharmaceutical Sciences & National Glycoengineering Research Center, Shandong University.
2008 – 2010 Lecturer, School of Pharmaceutical Sciences & National Glycoengineering Research Center, Shandong University.
2006 – 2008 Postdoctoral Fellow, School of Pharmaceutical Sciences, Shandong University.
2001 – 2003 Lecturer, School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine,
1998 – 2001 Teaching Assistant in School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine
Research interests
Chemoenzymatic synthesis of heparin/heparan sulfate oligosaccharides
Natural polysaccharide drugs and glycoanalysis
Chemical and biotechnological modification of proteins and enzymes
Recent Publications
Chunhui Liu, Juan Lu, Fengshan Wang and Min Xiao. Isolation, structural characterization and immunological activity of an exopolysaccharide produced by Bacillus licheniformis 8-37-0-1. Bioresource Technology, 2010, 101(14):5528-5533
Juan Li, Chun Hui Liu and Feng Shan Wang. Thymosin alpha 1: Biological activities, applications and genetic engineering production. Peptides, 2010, 31(11): 2151-2158.
Yuhong Liu, Chunhui Liu, Haining Tan, Ting Zhao, Jichao Cao, Fengshan Wang. Sulfation of a polysaccharide obtained from Phellinus ribis and potential biological activities of the sulfated derivatives. Carbohydrate Polymers, 2009, 77(2): 370-375
Jinfeng Liu, Li Teng, Chunhui Liu, Fengshan Wang. Augmented inhibitory effect of superoxide dismutase on superoxide anion release from macrophages by chemical modification with polysaccharide and attenuation effects on radiation-induced inflammatory cytokine expression in vitro. Journal of Drug Targeting, 2009, 17(3): 216-224
Liang Ye, Qingfeng Zhou, Chunhui Liu, Tao Xi. Identification and fermentation optimization of a marine-derived Streptomyces Griseorubens with anti-tumor activity. Indian Journal OF Marine sciences, 2009, 38(1):14-21
Chunhui Liu, Xiaodong Li, Yuhua Li, You Feng, Shuai Zhou, Fengshan Wang. Structural characterization and antimutagenic activity of a novel polysaccharide isolated from Sepiella maindroni ink. Food Chemistry, 2008, 110(4): 807-813
Chunhui Liu, Tao Xi, Qinxiong Lin, Yingying Xing, Liang Ye, Fengshan Wang. Immunomodulatory activity of polysaccharides isolated from Strongylocentrotus nudus eggs. International Immunopharmacology, 2008, 4(13-14): 1835-1841
Yunmian He, Chunhui Liu, Yuxing Chen, Ancheng Ji, Zilong Shen, Tao Xi and. Isolation and structural characterization of a novel polysaccharide prepared form Arca subcrenata Lischke. Journal of Bioscience and Bioengineering, 2007,104(2): 111-116
Haining Tan, Shenglin Yang, Chunhui Liu, Fengshan Wang. Characterization and Secondary Structure Analysis of Endostatin Covalently Modified by Polyethylene Glycol and Low Molecular Weight Heparin. The Journal of Biochemistry, 2008, 144(2):207-213
Han Zhao, Lili Lu, Min Xiao, Qinpeng Wang, Chunhui Liu, et al. Cloning and characterization of a novel alpha-galactosidase from Bifidobacterium breve 203 capable of synthesizing Gal-alpha-1,4 linkage. FEMS Microbiology Letters, 2008, 285(2): 278-283
Subo Wang, Yanna Cheng, Fengshan Wang, Lirui Sun, Chunhui Liu, Xianjun Qu. Inhibition activity of sulfated polysaccharide of Sepiella maindroni ink on matrix metalloproteinase (MMP)-2. Biomedicine & Pharmacotherapy, 2008, 62(5): 297-302
Chunhui Liu, Qinxiong Lin, Liang Ye, et al. Characterization and antitumor activity of a polysaccharide from Strongylocentrotus nudus eggs. Carbohydate Polymers, 2007, 67(3): 313-318
Yunmian He, Yuxing Chen, Chunhui Liu, et al. Isolation,purification and immunological activity assay of polysaccharide from Arca subcrenata Lischke. Chinese Journal of Marine Drugs, 2007, 26(2):23-26 (in Chinese)
Chunhui Liu, Qinxiong Lin, Tao Xi, et al. Studies on Preparation and Anti-tumor Activity of the Polysaccharide from the Eggs of Strongylocentrotus nudus (SEP). Pharmaceutical Biotechnology, 2006, 13(6):429-432 (in Chinese)
Chunhui Liu, Qinxiong Lin, Tao Xi, et al. Extraction, purification and immunological activity assay of a polysaccharide from eggs of sea urchin Strongylocentrotus nudus. Chinese Journal of Marine Drugs, 2006, 25(3):7-11 (in Chinese)
Qinxiong Lin, Tao Xi, Chunhui Liu, et al. Preliminary research of bioactive metabolite produced by marine actinomyces M326. Chinese Journal of Marine Drugs, 2006, 25(1):4-9 (in Chinese)
Yi Gao, Chunhui Liu, Tao Xi, et al. Extraction, Purification and Antitumor Activity of a Protein from the Shell of Strongylocentrotus nudus. Chinese Journal of Natural Medicines, 2006, (6): 464-467 (in Chinese)
Qinxiong Lin, Chunhui Liu, Tao Xi, et al. Preliminary study of cytotoxic metabolite produced by marine actinomycete M313. Marine Sciences, 2006,(11):53-57 (in Chinese)
Funding
(1) National Natural Science Foundation of China (NSFC), 21372146, Jan 1, 2014 – Dec 31, 2014, Project leader
(2) National Science and Technology Major Project Foundation of China, 2011ZXJ09101-06C, Jan 1, 2011 – Dec 31, 2013, Project leader
(3) National Science and Technology Major Project Foundation of China, 2010ZX09401-302-4-8, Jan 1, 2010 – Dec 31, 2012, Project backbone
(4) Promotive research fund for excellent young and middle-aged scientisits of Shandong Province, BS2009SW024, Dec 1, 2009-Dec 31, 2012, Project leader
(5) Doctoral Fund of Ministry of Education of China （New Teachers), 20090131120051, Jan 1, 2010-Dec 31, 2012, Project leader
(6) The National Natural Science Foundation of China (NSFC), 30973678, Jan 1, 2010-Dec 31, 2012, Project backbone
(7) Special fund from post-doctor innovation research program of Shandong Province, 200703061, Jul 1, 2008-Oct 1, 2009, Project leader
(8) China Postdoctoral Science Foundation, 20060400984, Jan 1, 2007-Oct 1, 2008, Project leader
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