PERSONAL DATA:

Juzheng Sheng, Ph.D.

Associate Professor

Institute of Biochemical and Biotechnological Drug 

School of Pharmaceutical Sciences

Shandong University

Tel: 0531-88380288

E-mail: shengjuzheng@sdu.edu.cn

ADDRESS:
School of Pharmaceutical Sciences
Shandong University
No.44, Wenhuaxi Road, Jinan, 250012
P.R.China
Tel: 0086-531-88380288
E-mail:  shengjuzheng @sdu.edu.cn

PROFESSIOAN EXPERIENCE:
2012-Present     Associate Professor of Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences & National Glycoengineering Research Center, Shandong University.

2009-2012       Postdoctoral Research Associate of Medicinal Chemistry and Natural Products, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Mentor:         Professor Jian Liu.

RECENT PUBLICATION:
[1] X. Zhang, F. Wang*, J. Sheng *, “Coding” and “Decoding”: hypothesis for the regulatory mechanism involved in heparan sulfate biosynthesis, Carbohydrate Research. 428 (2016) 1–7. doi:10.1016/j.carres.2016.04.002.

[2] F.-X. Yin, F.-S. Wang*, J.-Z. Sheng*, Uncovering the Catalytic Direction of Chondroitin AC Exolyase FROM THE REDUCING END TOWARDS THE NON-REDUCING END, J. Biol. Chem. 291 (2016) 4399–4406. doi:10.1074/jbc.C115.708396.

[3] J. Xue, L. Jin, X. Zhang, F. Wang, P. Ling, J. Sheng*, Impact of donor binding on polymerization catalyzed by KfoC by regulating the affinity of enzyme for acceptor, Biochimica et Biophysica Acta (BBA) - General Subjects. 1860 (2016) 844–855. doi:10.1016/j.bbagen.2016.01.018.

[4] Y. Li, J. Hou, F. Wang*, J. Sheng*, High-throughput assays of leloir-glycosyltransferase reactions: The applications of rYND1 in glycotechnology, Journal of Biotechnology. 227 (2016) 10–18. doi:10.1016/j.jbiotec.2016.04.003.

[5] J.S. Xin Li, Phenylacrylamides as Novel FtsZ-targeted Potential Antimicrobials, Letters in Drug Design & Discovery. 12 (2015). doi:10.2174/1570180811666141009235409.

[6] J. Sheng*, P. Ling, F. Wang, Constructing a recombinant hyaluronic acid biosynthesis operon and producing food-grade hyaluronic acid in Lactococcus lactis, J Ind Microbiol Biotechnol. 42 (2015) 197–206. doi:10.1007/s10295-014-1555-8.

[7] Y. Xu, C. Cai, K. Chandarajoti, P.-H. Hsieh, L. Li, T.Q. Pham, E.M. Sparkenbaugh, J. Sheng, N.S. Key, R. Pawlinski, E.N. Harris, R.J. Linhardt, J. Liu*, Homogeneous low-molecular-weight heparins with reversible anticoagulant activity, Nat. Chem. Biol. 10 (2014) 248–250. doi:10.1038/nchembio.1459.

[8] Y. Xiao, P. Li, Y. Cheng, X. Zhang, J. Sheng, D. Wang, J. Li, Q. Zhang, C. Zhong, R. Cao, F. Wang*, Enhancing the intestinal absorption of low molecular weight chondroitin sulfate by conjugation with α-linolenic acid and the transport mechanism of the conjugates, Int J Pharm. 465 (2014) 143–158. doi:10.1016/j.ijpharm.2014.02.009.

[9] C. Liu, J. Sheng, J.M. Krahn, L. Perera, Y. Xu, P.-H. Hsieh, W. Dou, J. Liu*, L.C. Pedersen*, Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase, J. Biol. Chem. 289 (2014) 13407–13418. doi:10.1074/jbc.M113.530535.

[10] X. Guo, Y. Shi, J. Sheng, F. Wang*, A novel hyaluronidase produced by Bacillus sp. A50, PLoS ONE. 9 (2014) e94156. doi:10.1371/journal.pone.0094156.

[11] P. Li, J. Sheng, Y. Liu, J. Li, J. Liu, F. Wang*, Heparosan-derived heparan sulfate/heparin-like compounds: one kind of potential therapeutic agents, Med Res Rev. 33 (2013) 665–692. doi:10.1002/med.21263.

[12] J. Sheng, Y. Xu, S.B. Dulaney, X. Huang, J. Liu*, Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis, J. Biol. Chem. 287 (2012) 20996–21002. doi:10.1074/jbc.M112.359885.

[13] J. Liu*, A.F. Moon, J. Sheng, L.C. Pedersen, Understanding the substrate specificity of the heparan sulfate sulfotransferases by an integrated biosynthetic and crystallographic approach, Curr. Opin. Struct. Biol. 22 (2012) 550–557. doi:10.1016/j.sbi.2012.07.004.