Lupei Du’s Curriculum Vitae
EDUCATION
B. S. in Pharmaceutical Chemistry, July 1999, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China
Ph. D. in Medicinal Chemistry, June 2006, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China
ACADEMIC EXPERIENCES
Ph.D. Thesis, 2001.9 – 2006.6
Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
Project: Rational Design, Synthesis and Structure-Activity Relationship Studies of Ikr and Iks dual potassium channel blockers as antiarrythmic agents
Advisor: Prof. Qidong You and Prof. Lin Xia
Postdoctoral Research Associate, 2006. 9 – 2009.4
Department of Chemistry, Georgia State Univeristy, Atlanta, GA 30303, USA
Princial Investigator : Dr. Binghe Wang
Associate Professor, 2009.5-now
Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China
HONORS AND AWARDS
Outstanding thesis award in Nanjing, November 2005
Honor postgraduate student, May 2004
B.S. dissertation with honor, July 1999
Undergraduate fellowship for four years, 1995-1999
Member of China Pharmaceutical Association
PUBLICATION LIST
Papers and reviews in journals
1. Du, L. P.; Tsai, K. C.; Li, M. Y.; You, Q. D.; Xia, L. The pharmacophore hypotheses IKr potassium channel blockers: novel class III antiarrhythmic agents. Bioorg. Med. Chem. Lett. 2004, 14, 4771-4777.
2. Du, L. P.; Li, M. Y.; Tsai, K. C.; You, Q. D.; Xia, L. Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification. Biochem. Biophys. Res. Commun. 2005, 332, 677-687.
3. Du, L. P.; Li, M. Y.; You, Q. D.; Xia, L. A novel structure-based virtual screening model for the hERG channel blockers. Biochem. Biophys. Res. Commun. 2007, 355, 889-894.
4. Yang, Q.; Wang, Y. J.; Du, L. P.; Li, M. Y.; You, Q. D. Strategies for atrial fibrillation therapy: focusing on IKur potassium channel. Expert Opin. Ther. Patents 2007, 17, 1443-1456.
5. Du, L. P.; Li, M. Y.; Zheng, S. L.; Wang, B. H. Rational design of a fluorescent hydrogen peroxide probe based on the umbelliferone fluorophore. Tetrahedron Lett. 2008, 49, 3045-3048.
6. Yang, Q.; Du, L. P.; Wang, X. J.; Li, M. Y.; You, Q. D. Modeling the binding modes of Kv1.5 potassium channel and blockers. J. Mol. Graph. Model. 2008, 27, 178-187.
7. Li, M. Y.; Fang, H.; Du, L. P.; Xia, L.; Wang, B. H. Computational studies of the binding site of α1A-adrenoceptor antagonists. J. Mol. Model. 2008, 14, 957-966.
8. Yang, Q.; Du, L. P.; Wang, X. J.; Li, M. Y.; You, Q. D. Pharmacophore Mapping for Kv1.5 Potassium Channel Blockers. QSAR Comb. Sci. 2009, 28, 59-71.
9. Du, L.P.; Li, M. Y.; Yang, Q.; Tang, Y.Q.; You, Q.D.; Xia, L. Molecular hybridization, synthesis, and biological evaluation of novel chroman IKr and IKs dual blockers. Bioorg. Med. Chem. Lett. 2009, 19, 1477-1480
10. Du, L. P.; Li, M. Y.; You, Q. D. The interactions between hERG potassium channel and blockers. Curr. Top. Med. Chem. 2009, 9, 330-338.
11. Yang, Q.; Wang, X. J.; Du, L. P.; Li, M. Y.; You, Q. D. Drug discoveries towards Kv1.5 potassium channel. Curr. Top. Med. Chem. 2009, 9, 339-347.
12. Yang, Q.; Wang, X. J.; Du, L. P.; Li, M. Y.; You, Q. D. Drug discoveries towards Kv1.5 potassium channel. Curr. Top. Med. Chem. 2009, 9, 339-347.
13. Du, L.P., Ni, N.T., Li, M.Y. and Wang, B.H., A Fluorescent Hydrogen Peroxide Probe Based on a ‘Clickable’ Coumarin Fluorophore, Tetrahedron Lett. 2010, 51, 1152-1154.
14. Du, L.P. and Li, M.Y. , Modeling the Interactions Between α1-Adrenergic Receptors and Their Antagonists, Curr. Comput. Aid. Drug Des. 2010, 6, 165-178.
15. Sun, W., Du, L.P. and Li, M.Y., Aptamer-based Carbohydrate Recognition, Curr. Pharm. Des., 2010, 16, 2269-2278.
16. Yang, Q., Fedida, D., Xu, H., Wang, B., Du, L.P., Wang, X., Li, M.Y. and You, Q.D. Structure-Based Virtual Screening and Electrophysiological Evaluation of New Chemotypes of Kv1.5 Channel Blockers, ChemMedChem, 2010, 5, 1353-1358.
17. Liu, Z.Z., Du, L.P.* and Li, M.Y. Update on The Slow Delayed Rectifier Potassium Current (IKs): Role in Modulating Cardiac Function. Curr. Med. Chem. 2012, 19, 1405-1420.
18. Sun, W., Du, L.P.* and Li, M.Y. Bifunctional Fluorescent Probes for Hydrogen Peroxide and Carbohydrates Based on a 1,8-Naphthalimides Fluorophore. Sci. China Chem. 2013, in publish
Patents
1. You, Q.D., Du, L.P., Li, M.Y. and Xia, L., A Chroman Compound, Processes for Its Preparation, and Its Pharmaceutical Use, US Patent in filing, Application No. 20080103307, Sept 9, 2007
2. You, Q.D.; Du, L.P.; Li, M.Y.; Xia, L. Preparation of 2,3-Dihydrobenzopyran Derivatives as Antiarrhythmics. CN 1944428, Oct. 17, 2006
3. You, Q.D.; Du, L.P.; Li, M.Y.; Xia, L. Preparation and Application of Aromatic Formylpiperazine Compound Used in Medicines for Treating Arrhythmia. CN 1944424, Oct. 17, 2006
4. You, Q.D.; Du, L.P.; Yang, Q.; Li, M.Y.; Xia, L. Preparation of Indole Alkyl Amine Compounds and Application in Medicines”, CN 1944404, Oct. 17, 2006
5. You, Q.D.; Du, L.P.; Yang, Q.; Li, M.Y.; Xia, L. Preparation and Application of Benzimidazole Compounds. CN 1944416, Oct. 17, 2006
6. Xia, L.; Du, L.P.; Chen, W.H. Process for Preparation of 1-Amino-3-(azacycloalkyl)-2,4-imidazolediones. CN 1858039, Apr. 30, 2005
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